Correlation of leptin and soluble leptin receptor levels with anthropometric parameters in mother-newborn pairs.
نویسندگان
چکیده
The aim of this study was to investigate if anthropometric parameters are associated with both leptin and soluble leptin receptor (sLEPR) levels in newborns and their mothers. This cross-sectional study was performed in 118 mother-newborn pairs. The venous blood sample of mothers was taken before delivery and immediately after delivery an umbilical cord blood sample was collected. Levels of leptin and sLEPR in maternal and umbilical cord sera were assessed by ELISA. Maternal serum concentration of leptin and sLEPR (6.2 and 25.7 ng/ml, respectively) were higher than in umbilical cord blood (2.4 and 14.2 ng/ml, respectively). However, the newborns and their mothers had higher sLEPR levels than leptin levels. In mothers was observed that leptin levels increase with weight gain in pregnancy and decreased sLEPR levels. Cord leptin levels correlated with neonatal birth weight and length, the body circumferences, placental weight and maternal leptin levels. Cord sLEPR levels correlated with maternal sLEPR and leptin levels. Maternal serum concentration of leptin correlated with pre-pregnancy BMI, weight gain, cord sLEPR and leptin levels. Maternal sLEPR concentration correlated with cord sLEPR levels. The leptin and sLEPR levels in mother-newborn pairs are related with anthropometric parameters and an inverse correlation between leptin levels and sLEPR was observed in pairs.
منابع مشابه
Serum Leptin and Ghrelin Levels in Women with Polycystic Ovary Syndrome: Correlation with Anthropometric,Metabolic, and Endocrine Parameters
متن کامل
بررسی ارتباط رزیستین بند ناف با لپتین، انسولین، اندکس‌های رشدی و درصد چربی نوزادان تازه متولد شده در بیمارستان آیت الله موسوی زنجان در سال1388
Background and Objective: Resistin is a novel adipokine which may play a role in insulin resistance. In this study we aimed to determine the cord blood resistin, leptin, insulin and maternal serum resistin levels during pregnancy and to investigate correlation between these metabolic hormones and also to evaluate their association with newborn growth indices. Materials and Methods: This study w...
متن کاملبررسی ارتباط لپتین سرم با شاخص‌های آزمایشگاهی و انتروپومتریک سوء تغذیه در بیماران تحت همودیالیز
Background and Aim: Protein- energy malnutrition is a major problem and one of the risk factors in increasing mortality in hemodialysis patients. Since there is not any single index in the evaluation of nutritional status in these patients, leptin can be used as one of the parameters in this process. In this study, the correlation between serum leptin and biochemical and anthropometric parame...
متن کاملEffect of leptin receptor Q223R polymorphism on breast cancer risk
Objective(s):Leptin receptor (LEPR) is a member of the class I cytokine receptor super-family that is known implicated in the initiation and progression of breast cancer. We have investigated the effect of Q223R polymorphism on the breast cancer susceptibly in a sample of Iranian subjects. Materials and Methods:We utilized a polymerase chain reaction (PCR) restriction fragment length polymorphi...
متن کاملمطالعه سطح سرمی هورمون لپتین در زنان با درجات مختلف چاقی
Background: Leptin is a peptide strongly correlated with adiposity and is a potential determinant of obesity and its complications. The aim of this study was to evaluate the correlation between serum leptin levels and different anthropometric indices among obese women.Methods: This analytical descriptive study consisted of 106 women with different grade of obesity (BMI ³ 25 kg/m2) and 38 women ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- International journal of clinical and experimental medicine
دوره 8 7 شماره
صفحات -
تاریخ انتشار 2015